In this paper, we develop continuum models to establish that a gold NP and a silica NP approaches the plasma membrane (PM) differently due to the corresponding differences in the gold-NP-PM and silica-NP-PM van der Waals interactions. This is Haoyuan’s 12th paper, Harnoor’s 10th paper, and Shayandev’s 25th paper from the group. Congrats all !!!